Belantamab mafodotin: mechanism of action
Belantamab mafodotin
About Multiple Myeloma
MM is characterized by the uncontrolled growth of malignant plasma cells. All MM cells express BCMA. The incidence of MM is increasing despite improved outcomes with currently available therapies. The clinical course typically results in disease recurrence with progressively shorter disease-free intervals, highlighting the need for novel, effective, targeted agents.13,15-17
What is BCMA?
BCMA is a membrane protein that supports myeloma cell proliferation and survival. Belantamab mafodotin specifically binds to BCMA and eliminates myeloma cells by a multimodal mechanism including delivering mafodotin to BCMA-expressing malignant cells, enhancing ADCC/ADCP, and by potentiating immunogenic cell death.12-14
ADCC/ADCP, antibody-dependent cellular cytotoxicity/antibody-dependent cellular phagocytosis; BCMA, B-cell maturation antigen; MM, multiple myeloma
